A new application note entitled Direct Analysis of Red Wine Using Ultrafast Chromatography is now available from Thermo Fisher Scientific. It explains the capabilities of ultra-high pressure liquid chromatography coupled to an Orbitrap mass spectrometer for use in the identification and quantitation of antioxidant constituents in red wine. It demonstrates the potential of a direct analysis of red wine using the high resolving power of both the Accela and the LTQ Orbitrap XL. Researchers identified phenolic compounds responsible for most health benefits associated with red wine, such as quercetin and observed variable content across two different harvest years. Comparative analyses were performed using SIEVE 1.2 software. The features were filtered for statistical significance, with significant change defined as a minimum of two-fold concentration difference between the two years. The results presented in the application note show statistically significant changes for individual compounds detected. The concentration differences for some compounds, particularly quercetin, were considerable. The combination of the two systems provides a means of profiling complex mixtures as well as identification and advanced structural characterisation of detected compounds without prior sample preparation

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