Informing Spectroscopists for Over 40 Years

Bioorthogonal photocatalytic reactions of flavins converting Pt-VI substrates into Pt-II anticancer drugs

Platinum-based chemotherapy drugs have been life changing for many, with the most common drug, Cisplatin, providing treatment and cures for cancerous diseases in the bladder, breast, cervix, lung, ovaries, and head and neck, to name a few. However, PtII is used in these drugs, which is toxic to normal cells as well. However, non-active (prodrug) PtVI versions have minimal toxicity. This application describes the use of transient absorption spectroscopy and luminescence spectroscopy to investigate the Pt reduction process.