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Dried Blood Spot Bioanalysis: Addressing the Sensitivity Challenge

Dried blood spots (DBS) have been used for many years in neonatal testing using either a heel or finger prick onto a piece of paper which is then dried and shipped for analysis. This approach has now been applied to the field of bioanalysis in preclinical, toxicokinetic, and clinical studies. DBS has several benefits.

Friday, September 3, 2010

Dried Blood Spot Bioanalysis: Addressing the Sensitivity Challenge

MALDI imaging for fingermark analysis

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fingerprint-sA new technique to analyse fingermarks from crime scenes has the potential to give crucial additional details about a suspect such as their medications, diet, the time at which they accidentally left the fingermark and can even be used to detect any substances they might have touched, such as traces of cocaine. These extra details can be important background information in a criminal investigation, especially if the suspect's fingerprint is not on the police database. It is hoped the technique will compliment current fingermark detection techniques and assist in criminal investigations.

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US Army researchers explore LIBS

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US-Army-LIBS-sThe US Army Research Laboratory is working on laser-induced breakdown spectroscopy (LIBS), which has shown significant advances since its inception in the 1980s. Today, LIBS technology is used for multiple purposes, including the 2011 mission to Mars, detection of chemical, biological, radiological, nuclear and explosive (CBRNE) material, and materials matching in forensic cases.

Read more: US Army researchers explore LIBS

 

Spectroscopy at the World Cup

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World-Cup-NIR-2011-sDoping remains a problem throughout sport despite increases in technology to catch the cheats and increased sampling of competitors. At the World Cup, due to start on 11 June, two mass spectrometry companies are providing instrumentation for the anti-doping labs. AB Sciex is providing LC-MS/MS instrumentation and Agilent, GC/MS systems.

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Raman shows potential of graphene

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graphene-sRaman spectroscopy has been used to show that graphene has the potential to replace carbon fibres in high performance materials that are used to build aircraft. Graphene—discovered in 2004 by physicists Professor Andre Geim and Dr Kostya Novoselov at The University of Manchester—is a two-dimensional layer of carbon atoms that resembles chicken wire.

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Atomic vapour nano-layers—a tool for ultra-high resolution laser spectroscopy

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doppler-F2-sThe Doppler effect is of fundamental importance in laser spectroscopy. The atoms and molecules in the ensemble under observation perform continuously movements with velocities grouped around one central frequency value which is determined by the ensemble’s temperature. This temperature movement of atoms leads to a spectral broadening of the transitions and so limits the application of many devices and methodologies. For atoms enclosed in cells with centimetre-scale size, the laser beam “sees” the atomic ensemble in the same way—with the same velocity distribution of atoms independently of the propagation direction trough the cell. In this case we say that the velocity distribution of atoms is spatially isotropic.

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New MS method to identify glycosylated proteins

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Mann_CellA new mass spectrometry-based method allows the identification of N-glycosylated protein sites in different tissues in a highly efficient way. It has enabled the identification of 6367 N-glycosylated protein sites.

Read more: New MS method to identify glycosylated proteins

   

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