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Dried Blood Spot Bioanalysis: Addressing the Sensitivity Challenge

Dried blood spots (DBS) have been used for many years in neonatal testing using either a heel or finger prick onto a piece of paper which is then dried and shipped for analysis. This approach has now been applied to the field of bioanalysis in preclinical, toxicokinetic, and clinical studies. DBS has several benefits.

Friday, September 3, 2010

Dried Blood Spot Bioanalysis: Addressing the Sensitivity Challenge

Synchrotron imaging of single starch granules

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David Wetzel and Yong-Cheng Shi of Kansas State University, USA, and John Reffner from John Jay College, City University of New York, USA have applied microscopic chemical imaging to single modified starch granules. Starch manufacturers can use this to determine if the modifying agent used in the production process is uniformly distributed across individual modified starch granules. Mark Boatwright, a K-State graduate research assistant in grain science and industry assisted with data processing for the study.

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XAS station on Diamond light source

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The first researchers have arrived on the latest experimental station to become operational at the Diamond Light Source, the UK’s national synchrotron facility. The new experimental station (B18) offers X-ray Absorption Spectroscopy (XAS).

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MS shows aspirin target COX-2 lipids have anti-oxidant properties

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Lipids produced by the aspirin target COX-2 have anti-oxidant and anti-inflammatory properties as presented in a study published online this week in Nature Chemical Biology (doi: 10.1038/nchembio.367).

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Locating metal complexes within living cells with Raman microscopy

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The location of metal complexes within living cancer cells has been accurately determined using Raman microscopy. The researchers have thus gained new insights into the mechanism of action of metal-containing drugs, to which they ascribe great potential capacities, e.g. in the treatment of cancer. These findings are of fundamental significance and are thus featured as a VIP (very important paper) in the current edition of Angewandte Chemie.

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Global food safety response center

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Thermo Fisher Scientific has opened a global food testing laboratory devoted to helping contain costly and life-threatening chemical contamination crises. The Food Safety Response Center, located in Dreieich, Germany, is equipped with state-of-the-art equipment and staffed by world-class chemists who will quickly mobilise to aid governments and businesses facing an unknown food safety threat involving chemical contaminants. One recent threat, the melamine crisis in China, claimed the lives of at least six children, made nearly 300,000 ill and cost companies worldwide billions before it was contained.

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European Magnetic Resonance Awards 2010

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The recipients of the 2010 European Magnetic Resonance Awards are John R. Griffiths (Basic Sciences) for his contributions to the applications of magnetic resonance spectroscopy in oncology, and Stefan Neubauer (Medical Sciences) for his contributions to anatomical and functional cardiovascular magnetic resonance imaging and spectroscopy.

Read more: European Magnetic Resonance Awards 2010

   

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