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Dried Blood Spot Bioanalysis: Addressing the Sensitivity Challenge

Dried blood spots (DBS) have been used for many years in neonatal testing using either a heel or finger prick onto a piece of paper which is then dried and shipped for analysis. This approach has now been applied to the field of bioanalysis in preclinical, toxicokinetic, and clinical studies. DBS has several benefits.

Friday, September 3, 2010

Dried Blood Spot Bioanalysis: Addressing the Sensitivity Challenge

MR spectroscopy may help diagnose, determine aggressiveness of prostate cancer

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Magnetic resonance (MR) spectroscopy may in the future be able both to pinpoint the precise location of prostate cancer and to determine the tumour's aggressiveness, information that could help guide treatment planning. In Science Translational Medicine (doi: 10.1126/scitranslmed.3000513), Massachusetts General Hospital (MGH) researchers report how spectroscopic analysis of the biochemical makeup of prostate glands accurately identified the location of tissue confirmed to be malignant by conventional pathology.

Read more: MR spectroscopy may help diagnose, determine aggressiveness of prostate cancer

 

NIR shows babies' brains tuned to sharing attention with others

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baby-sChildren as young as five months old will follow the gaze of an adult towards an object and engage in joint attention, according to research at Birkbeck, University of London, funded by the Wellcome Trust and the Medical Research Council. The findings, published in Biology Letters (doi: 10.1098/rsbl.2009.1069), suggest that the human brain develops this important social skill surprisingly early in infancy.

Read more: NIR shows babies' brains tuned to sharing attention with others

 

Raman sheds new light on cancer

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Researchers at the University of St Andrews have developed a powerful technique that could allow earlier cancer detection. In a joint venture between the Schools of Physics & Astronomy and the Bute Medical School, the St Andrews researchers have advanced new technology that relies on Raman spectroscopy.

Read more: Raman sheds new light on cancer

   

European Commission clears proposed acquisition of Varian by Agilent, subject to conditions

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The European Commission has cleared, under the EU Merger Regulation, the proposed acquisition of Varian Inc. by Agilent Technologies Inc., both US companies, by way of purchase of shares. The decision is conditional upon the divestment of Agilent's entire micro/portable gas chromatography instrument business and Varian's entire laboratory gas chromatography, triple quadrupole gas chromatography-mass spectrometry and inductively coupled plasma-mass spectrometry instrument businesses. In view of the remedies proposed, the Commission has concluded that the operation would not significantly impede effective competition in the European Economic Area (EEA) or any substantial part of it.

Read more: European Commission clears proposed acquisition of Varian by Agilent, subject to conditions

   

Pittcon 2010 Awards

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The winners of the 2010 Pittcon Awards include a good number of spectroscopists, and names that will be familiar to readers.

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Instantaneous trace gas fingerprint with laser frequency combs

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high-finesse-cavity-for-laser-frequency-combs-sTrace gas spectroscopic detection has drawn much interest in recent years, as it both allows a better understanding of the molecular spectra of weak overtone transitions and in situ non-intrusive sensing of compounds at low concentration. However, recording a broadband spectrum within a very short measurement time and with high sensitivity remains a challenge. Now, scientists at the Max Planck Institute of Quantum Optics have recorded ultrasensitive absorption broadband spectra within tens of microseconds by combining cavity enhancement and frequency comb spectroscopy.

Read more: Instantaneous trace gas fingerprint with laser frequency combs

   

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