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Dried Blood Spot Bioanalysis: Addressing the Sensitivity Challenge

Dried blood spots (DBS) have been used for many years in neonatal testing using either a heel or finger prick onto a piece of paper which is then dried and shipped for analysis. This approach has now been applied to the field of bioanalysis in preclinical, toxicokinetic, and clinical studies. DBS has several benefits.

Friday, September 3, 2010

Dried Blood Spot Bioanalysis: Addressing the Sensitivity Challenge

Tracking valence electrons in real time with pump–probe spectroscopy

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Laser pulses lasting less than 150 attoseconds have been used to observe, in real time, the motion of electrons in the outermost (“valence”) shell of ionised krypton atoms. This technical achievement, reported in Nature 466(7307), 739–742, lays the groundwork for observations in more complex systems, which should allow a detailed examination of the fundamental processes underlying the making and breaking of chemical bonds.

Read more: Tracking valence electrons in real time with pump–probe spectroscopy

 

AFM and spectroscopic techniques determine unknown structure

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Microscopy with atomic resolution could be useful in the determining the structure of some unknown organic compounds, such as medicinally important natural products, according to a study online in Nature Chemistry. This method could avoid the lengthy and expensive process of trying to synthesise the compound and then compare its structure with that of the natural one, which is necessary in some cases.

Read more: AFM and spectroscopic techniques determine unknown structure

 

Tracking a chemical reaction using molecular interference

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A new technique for following chemical reactions in real time makes a virtue of necessity, by using the radiation from non-reacting molecules as part of the detection method. As reported in Nature, this implementation of “high-harmonic interferometry” can be used to monitor both molecular structure and electron dynamics, the latter with attosecond time resolution.

Read more: Tracking a chemical reaction using molecular interference

   

Association of British Spectroscopists (ABS) Trust Fund Bursaries 2010

The ABS Trust invites UK-based university students undertaking spectroscopy research or utilising spectroscopy as a major component of their research to apply for a bursary award to attend a recognised scientific meeting to present an oral or poster presentation or to visit a place of learning to advance their spectroscopy knowledge and understanding.

More details and an application form may be requested from John Chalmers at This e-mail address is being protected from spambots. You need JavaScript enabled to view it

   

XRF unveils Leonardo Da Vinci’s faces

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Louvre1-sHow did Leonardo Da Vinci manage to paint such perfect faces? XRF analysis has shown the composition and thickness of each layer of material laid down by the painter. The results reveal that, in the case of glazes, thin layers of 1–2 µm have been applied.

Read more: XRF unveils Leonardo Da Vinci’s faces

   

NMR at new research centre makes important discovery in protein regulation

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The new Jean Jeener Bio-NMR Centre at the VIB Department of Molecular and Cellular Interactions, Vrije Universiteit Brussel, has already played a role in a scientific breakthrough that has been published Cell. Thanks to NMR, it is possible to determine the dynamic structure of proteins, and it was used to find out how the activity of certain proteins involved in the stress physiology of bacteria is regulated.

Read more: NMR at new research centre makes important discovery in protein regulation

   

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