ChemImage will present the results of an ingredient-specific particle sizing (ISPST) study on a combination metered dose inhaler product at Respiratory Drug Delivery (RDD) 2010 (www.rddonline.com). This conference takes place from 25 to 29 April in Orlando, Florida, USA, and covers current biological and pharmaceutical issues related to nasal and respiratory drug delivery.

ChemImage researchers will present "Ingredient-specific particle sizing of combivent metered dose inhaler" in which results from a wide-field Raman chemical imaging study of drug particle size distribution of two active pharmaceutical ingredients (APIs) in a Metered Dose Inhaler (MDI) will be discussed.

"This study is meant to provide drug developers with guidance on how they can utilise a new analytical method to characterise an inhalation product with more than one active pharmaceutical ingredient," said Dr Ryan Priore, Director of Applications and Contract Services. "This has historically been very difficult and time consuming with current methods such as cascade impaction and HPLC. Raman chemical imaging can provide a more efficient and accurate alternative for these combination products."

This novel approach to characterisation of a combination drug product enables the identification of each API via a unique Raman signature and ingredient-specific particle sizing as a result of a chemical image analysis. This information can be especially useful during product development and formulation, providing valuable information about product quality and performance prior to entering into expensive clinical trials.

User Rating: / 2
PoorBest