Spectroscopy Since 1975

Raman bioprocess monitoring

12 April 2021 | Product
by Ian Michael

A process analytical technology (PAT) solution has been introduced for real-time monitoring of bioprocesses without compromising the sterile boundary. SCHOTT, INFORS HT and tec5 have announced a product combination for the direct use of Raman spectroscopy in bioreactors. This is a combination of bioreactor, spectrometer system and probe receptacle, and meets typical instrumental and regulatory requirements. The new system integrates sensors into bioprocesses thanks to standardised interfaces. Measuring points can also be changed easily.

The system includes the bioreactor Minifors 2 and eve® bioprocess software from INFORS HT; the latter enabling users to centralise all bioprocess data in one database. Attached to the bioreactor port is the SCHOTT ViewPort™ sterile optical sensor receptacle. It features a hermetically sealed optical window made of sapphire for in situ process monitoring with optical sensors. Dedicated Raman spectrometer systems from tec5 have been specifically adapted to fit the different variants of SCHOTT’s ViewPort™.

The ViewPort™ sensor receptacle can be attached to standard bioreactor ports, such as an ingold or PG13.5. The bioreactor and integrated ViewPort™ can then be sterilised as usual using γ-radiation or steam-in-place (SIP). Finally, the spectrometer probe is mounted with high positional accuracy on the ViewPort™ components during operation using a quick-release fastener. It is also easy and safe to change the probe between different ports. All components are manufactured using materials in accordance with pharma industry best practices, making the system ideally suited for use in regulated areas, such as Good Manufacturing Practice (GMP) and hygienic design.

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